Experiences are what make a vacation. Looking back on your most cherished memories, what springs to mind first—an opulent hotel with all the bells and whistles? A life-affirming adventure, a profound experience? Or a trip that pushes you way out of your comfort zone and truly challenges you? Of course, having a cushy place to rest your weary head at the end of the day is always welcome, but it’s the stuff in between that makes up the fabric of our most treasured times. This year, our Top Adventures all have the underpinning of responsible luxury—be it a donation included in the price or an immersion in a local community. And, in some cases, assisting the scientific community with a record-breaking excursion.